2017

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2017/№12

Hypertrophic Cardiomyopathy and Ischemic Heart Disease. Variants of Combination Pathology

Kaplunova V. Yu., Shakaryants G. A., Kozhevnikova M. V., Ilgisonis I. S., Privalova E. V., Khabarova N. V., Naymann Yu. I., Belenkov Yu. N., Shakaryants V. A.
I. M. Sechenov First Moscow State Medical University, Moscow, Russia

Keywords: hypertrophic cardiomyopathy; prognosis; myocardial bridging; ischemic heart disease; modifier gene polymorphisms

DOI: 10.18087/cardio.2017.12.10062

The issues of epidemiology and pathophysiology of hypertrophic cardiomyopathy (HCMP), as well as the search for its additional clinical-instrumental and genetic markers, environmental factors capable to influence the formation of its clinical variant and prognosis are subjects of great interest to the modern scientific community. Besides genetic markers of main neurohumoral systems, and morphofunctional parameters of intracardiac hemodynamics clinical course of the disease is influenced by a complex of concomitant pathology including ischemic heart disease (IHD), joining of which is possible in 10% of cases. IHD substantially aggravates course of HCMP and hampers selection of medical therapy. It should be noted that prognosis of primary hypertrophies is affected by episodes of ischemia of complex genesis and addition of IHD significantly increases risk of sudden death in these patients.
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Kaplunova V. Yu., Shakaryants G. A., Kozhevnikova M. V., Ilgisonis I. S., Privalova E. V., Khabarova N. V., Naymann Yu. I., Belenkov Yu. N., Shakaryants V. A. Hypertrophic Cardiomyopathy and Ischemic Heart Disease. Variants of Combination Pathology. Kardiologiia. 2017;57(12):16–24.

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